Research project, still in progress, with the title “Radiation action mechanisms at the level of nervous system tumours and enhancing the effect of the radiation through drugs”

Pucci S, Fasoli F, Moretti M, Benfante R, Di Lascio S, Viani P, Daga A, Gordon TJ, McIntosh M, Zoli M, Clementi F and Gotti C (2021) Choline and nicotine increase glioblastoma cell proliferation by binding and activating alpha7- and alpha9- containing nicotinic receptors. Pharmacol Res 163: 105336.

Bavo F, Pallavicini M, Gotti C, Appiani R, Moretti M, Colombo SF, Pucci S, Viani P, Budriesi R, Renzi M, Fucile S and Bolchi C (2020) Modifications at C(5) of 2-(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent alpha4beta2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the alpha3beta4 Subtype. J Med Chem 63(24): 15668-15692.

Zoli M, Pucci S, Vilella A and Gotti C (2018) Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. Curr Neuropharmacol 16(4): 338-349.

Mucchietto V, Fasoli F, Pucci S, Moretti M, Benfante R, Maroli A, Di Lascio S, Bolchi C, Pallavicini M, Dowell C, McIntosh M, Clementi F and Gotti C (2018) Alpha9- and alpha7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line. Br J Pharmacol 175(11): 1957-1972.

Bavo F, Pucci S, Fasoli F, Lammi C, Moretti M, Mucchietto V, Lattuada D, Viani P, De Palma C, Budriesi R, Corradini I, Dowell C, McIntosh JM, Clementi F, Bolchi C, Gotti C and Pallavicini M (2018) Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an alpha7-nAChR, alpha9-nAChR Antagonist and of a Pro-Oxidant Mitocan. J Med Chem 61(23): 10531-10544.

Fasoli F, Moretti M, Zoli M, Pistillo F, Crespi A, Clementi F, Mc Clure-Begley T, Marks MJ and Gotti C (2016) In vivo chronic nicotine exposure differentially and reversibly affects upregulation and stoichiometry of alpha4beta2 nicotinic receptors in cortex and thalamus. Neuropharmacology 108: 324-331.

Pistillo F, Fasoli F, Moretti M, McClure-Begley T, Zoli M, Marks MJ and Gotti C (2016) Chronic nicotine and withdrawal affect glutamatergic but not nicotinic receptor expression in the mesocorticolimbic pathway in a region-specific manner. Pharmacol Res 103: 167-176.

Mucchietto V, Crespi A, Fasoli F, Clementi F and Gotti C (2016) Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des 22(14): 2160-2169.

Matera C, Quadri M, Sciaccaluga M, Pome DY, Fasoli F, De Amici M, Fucile S, Gotti C, Dallanoce C and Grazioso G (2016) Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the alpha3beta4 nicotinic acetylcholine receptor subtype. Eur J Med Chem 108: 392-405.

Bolchi C, Bavo F, Fumagalli L, Gotti C, Fasoli F, Moretti M and Pallavicini M (2016) Novel 5-substituted 3-hydroxyphenyl and 3-nitrophenyl ethers of S-prolinol as alpha4beta2-nicotinic acetylcholine receptor ligands. Bioorg Med Chem Lett 26(23): 5613-5617.

Bolchi C, Valoti E, Gotti C, Fasoli F, Ruggeri P, Fumagalli L, Binda M, Mucchietto V, Sciaccaluga M, Budriesi R, Fucile S and Pallavicini M (2015) Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed as alpha4beta2-Nicotinic Acetylcholine Receptor Agonists. J Med Chem 58(16): 6665-6677.

Fasoli F and Gotti C (2015) Structure of neuronal nicotinic receptors. Curr Top Behav Neurosci 23: 1-17.

Filipello F, Morini R, Corradini I, Zerbi V, Canzi A, Michalski B, Erreni M, Markicevic M, Starvaggi-Cucuzza C, Otero K, Piccio L, Cignarella F, Perrucci F, Tamborini M, Genua M, Rajendran L, Menna E, Vetrano S, Fahnestock M, Paolicelli RC, Matteoli M. (2018) The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity. Immunity 48(5):979-991.e8. doi: 10.1016/j.immuni.2018.04.016. Epub 2018 May 8

Tamborini M, Locatelli E, Rasile M, Monaco I, Rodighiero S, Corradini I, Franchini MC, Passoni L, Matteoli M (2016) A novel approach combining Chlorotoxin-nanovector and low dose radiation to reach infiltrating tumor niches in glioblastoma. ACS Nano, in press, doi: 10.1021/acsnano.5b07375. Epub 2016 Feb 9. 

Mazzitelli S, Filipello F, Rasile M, Lauranzano E, Starvaggi-Cucuzza C, Tamborini M, Pozzi D, Barajon I, Giorgino T, Natalello A, Matteoli M. (2016) Amyloid-β 1-24 C-terminal truncated fragment promotes amyloid-β 1-42 aggregate formation in the healthy brain. Acta Neuropathol Commun. 4(1):110. doi:10.1186/s40478-016-0381-9.

Lara Pizzamiglio, Elisa Focchi, Luca Murru, Matteo Tamborini, Maria Passafaro, Elisabetta Menna, Michela Matteoli and Flavia Antonucci NEW ROLE OF ATM IN CONTROLLING GABAERGIC TONE AND HIPPOCAMPAL NEURONAL TRANSMISSION. Cereb Cortex. 2016 Oct;26(10):3879-88.

R Tomasoni, R Morini, J P. Lopez-Atalaya, I Corradini, A Canzi, M Rasile, C Mantovani, D Pozzi, C Garlanda, A Mantovani E Menna, A Barco and M Matteoli (2017) Lack of IL-1R8in neurons causes hyperactivation of IL-1 receptor pathway and induces MeCP2-dependent synaptic defects. eLife Mar 28;6. pii: e21735. doi: 10.7554/eLife.21735

Antonucci F, Corradini I, Fossati G, Tomasoni R, Menna E, Matteoli M* (2016) SNAP-25, a known presynaptic protein with emerging postsynaptic functions. Front Synaptic Neurosci. 2016 Mar 24;8:7.

I Corradini, E Focchi, M Rasile, R Morini, G Desiato, R Tomasoni, M Lizier, E Ghirardini, D Morone, I Barajon, Fl Antonucci, D Pozzi and M Matteoli (2018) MATERNAL IMMUNE ACTIVATION DELAYS EXCITATORY-TO-INHIBITORY GABA SWITCH IN THE OFFSPRING. Biol. Psy. 83(8):680-691